![]() ![]() While the serum levels remained within the accepted therapeutic range for most of them, two medications - clobazam and desmethylclobazam - had serum levels outside the therapeutic range. Researchers monitored the serum levels of the AEDs in subjects over time. ![]() The CBD doses were increased every 2 weeks. In another study, 39 adults and 42 children taking AEDs were also given CBD in the form of Epidiolex. They report that taking CBD and clobazam together is safe, but recommend monitoring medications levels during treatment. Researchers found elevated levels of the clobazam in these children. For example, in one study of 25 children with hard-to-treat epilepsy, 13 kids were given both clobazam and CBD. Some small clinical trials have been conducted. Studies have been done in animals for certain medications, but in many cases, scientists are still determining how those results translate to humans. Researchers are working to determine the specific interactions between CBD and various medications. Check your medication’s insert information or ask your doctor.Ĭurrent research on interactions between CBD and medications Grapefruit warnings are common in several types of medications, but not all medications within a category will require the avoidance of grapefruit. The result is a slowed metabolization of medications. That’s because chemicals in grapefruit known as furanocoumarins inhibit CYP3A4, in a similar fashion as CBD. More than 85 drugs interact with grapefruit and some closely related citrus juices - like Seville oranges, pomelos, and tangelos. This warning indicates that people taking the medication should avoid consuming grapefruit or grapefruit juice.Īccording to the Food and Drug Administration, consuming grapefruit while on one of these medications can lead to a higher concentration of the medication in the bloodstream and adverse side effects or even an overdose. Potential drug interactions Look for the grapefruit warningĪlthough studies are still ongoing to determine potential interactions between CBD and specific medications, there’s one rule of thumb that can help consumers in the meantime: Avoid CBD if your medications have a grapefruit warning on the label. Unlike oils, edibles, and vaping solutions, topicals don’t typically enter the bloodstream - as long as they’re not a transdermal solution intended to do so. Keep in mind that topical CBD, like lotions, creams, and salves, may also be an option. For some situations, your doctor may want to monitor blood plasma levels of certain medications you take.ĭon’t stop any of your medications to try CBD, unless your doctor says it’s safe to do so. They may be able to help determine a CBD product, dosage, and schedule that’s safe with your medications. ![]() If you want to try CBD as an add-on therapy to ease symptoms of a certain condition, talk to your doctor about it first. Trying CBD safely while taking medications If your body is metabolizing a medication too fast because another substance is inducing the enzymes, you may not have enough of the medication in your system at one time to treat a health issue. Some substances also speed up the work of the CYP450 enzyme family. An increased level of a medication in your system could exaggerate its effects, including unwanted or harmful side effects. If your body is metabolizing a medication too slowly, you may have more medication in your system at one time than intended - even if you’ve stuck to your normal dose. ![]() If you then take CBD while on these medications, your body can’t work to process the CBD as effectively. But if CBD is inhibiting CYP3A4, it can’t work as effectively to break down the medications in your system. The CYP3A4 enzyme is in charge of metabolizing about 60 percent of clinically prescribed medications. But during this process, CBD also interferes with CYP3A4. Specifically, CYP3A4, an important enzyme within the CYP450 family, does the task. The CYP450 family of enzymes is responsible for metabolizing several cannabinoids, including CBD, research shows. Why does CYP450 matter when it comes to CBD and medications? That change in metabolism rate can alter how your body processes the medications or supplements you take - hence a drug interaction. Drug metabolism happens throughout the body, such as in the gut, but the liver does a big part of the job, too.Ī family of enzymes called cytochrome P450 (CYP450) does the important work of converting foreign substances so they can easily be eliminated from the body.īut some medications or substances affect CYP450, either by slowing or speeding up drug metabolism. When you take a medication or other substance, your body has to metabolize it, or break it down. ![]()
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